For a 2016 study published in Brain Imaging and Behavior, researchers recruited 303 participants, a mix of only children and people with siblings. After taking an intelligence test, a personality test that measured the Big Five personality traits, and the Torrance Tests of Creative Thinking, the participants underwent MRI scans so researchers could get images of their brains. The tests showed that while both groups had similar intelligence levels, only children tended to exhibit more flexibility in their thinking—a key indicator of creativity—and less agreeableness. Previous research has found similar behavioral results, but where this study took it one further was by finding neurological differences between the two groups.
The MRI scans revealed a distinct difference in the volume of gray matter in the brains of only children and those of people with siblings. Only children showed more gray matter in a portion of their brain's parietal lobes called the supramarginal gyrus, which controls their language control and processing. The researchers correlated that difference with the only children's flexibility—i.e., their creative thinking.
On the flip side, only children demonstrated a lower volume of their brain's medial prefrontal cortex—the part of your brain that controls personality and social behaviors. Researchers linked this finding to those lower agreeableness scores.